Reversal of Severe Renal Failure in Systemic Sclerosis

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Abstract

Renal failure in systemic sclerosis, with or without malignant hypertension, is regarded as progressive and irreversible, leading to death within weeks to months (1, 2). We have recently seen a patient with systemic sclerosis and severe renal involvement who showed marked improvement in renal function while receiving chronic renal dialysis and antihypertensive therapy, permitting discontinuation of dialysis 1 year after onset of renal failure.

A 48-year-old black woman was hospitalized in June 1976 with a 1-month history of anorexia and fatigue, and shortness of breath on

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