Hypersthenuria and Carbenicillin

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Abstract

To the editor: We read with interest the paper by Zwelling and Balow in the August issue, “Hypersthenuria in High-Dose Carbenicillin Therapy” (Ann Intern Med 89:225–226, 1978). The authors may be interested to learn that we previously reported this phenomenon (1). Further, we suggested that, as a bedside rule, when a patient with normal kidney function is receiving carbenicillin, his real specific gravity could be calculated by subtracting from the measured specific gravity a factor equal to six times the urine carbenicillin concentration; that concentration is obtained by dividing 80% of the daily carbenicillin load by the 24-h urine volume.

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