Ambulatory Peritoneal Dialysis

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To the editor: With data on inulin and vitamin B12 clearances during continuous ambulatory peritoneal dialysis, Popovich and colleagues (1) have shown that the weekly clearances of these substances and, by extrapolation, of middle molecules are three times higher than those of conventional intermittent peritoneal dialysis and two to six times higher than those of hemodialysis.

We recently had the opportunity to measure middle-molecules plasma levels in four patients converted from intermittent peritoneal dialysis to continuous ambulatory peritoneal dialysis and in one patient converted from continuous ambulatory peritoneal dialysis to intermittent peritoneal dialysis (Figure 1). Measurement was by gel chromatography

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