Neck Radiation and Hyperparathyroidism

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To the editor: We have read with interest the recent reports of apparent radiation-induced hyperparathyroidism (1, 2). The reported fraction of hyperparathyroidism associated with radiation therapy to the neck is 14% to 30% (3, 4). Parathyroid lesions have included adenomas and hyperplasia.We have reviewed 66 cases of hyperparathyroidism seen by us over the last 4 years. Of the 66 patients, 44 (67%) were women (mean age, 55 years; range, 28 to 78 years) and 22 (33%) were men (mean age, 53 years; range, 36 to 65 years). Six patients (9%) had received antecedent radiation therapy to the neck, one

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