Neonatal Thrombocytopenia Complicating Autoimmune Thrombocytopenia in Pregnancy: Evidence for Transplacental Passage of Antiplatelet Antibody

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Abstract

Transient thrombocytopenia may occur in infants born to mothers suffering from autoimmune thrombocytopenic purpura (1) and is believed to result from transplacental passage of maternal immunoglobulin (Ig) G antiplatelet antibody (2). Although this humoral mechanism generally has been accepted (3), it has remained unproven, because the antibody has not been shown in either the serum or attached to the platelets of the affected child. A sensitive antiglobulin consumption assay that is capable of measuring nanogram amounts of platelet-bound IgG (platelet antibody) has recently been reported (4). This assay has enabled us to show that the thrombocytopenia occurring in a child

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