Nodular Non-Hodgkin's Lymphoma: The Case for Watchful Waiting

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This issue carries an unusual and provocative article (pp. 10–13) by Portlock and Rosenberg describing their experience with a “hands-off therapeutic approach to selected patients with good-prognosis forms of non-Hodgkin's lymphoma. Their article analyzes a 15-year experience with 44 patients in whom therapy was withheld until necessitated by progression of disease; this study contrasts with the general trend of clinical research in non-Hodgkin's lymphoma, which in recent years has been concerned with the application of intensive, and possibly curative, therapy at the time of diagnosis.

The importance of this article, and indeed the debate over “good prognosis” non-Hodgkin's lymphoma, can

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