Aspirin and Postoperative Bleeding

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To the editor: Torosian and colleagues (1) have reported increased postoperative bleeding in patients receiving aspirin within a week of surgery. Although the effects of aspirin last for the lifetime of exposed platelets, 5 to 7 days, the bleeding time is normal within 2 days after administration of aspirin (2, 3), and platelets collected from donors receiving aspirin 36 h before donation can correct abnormal bleeding times in recipients (4). Although aspirin-exposed platelets do not release their own ADP, if sufficient normal platelets are present the entire platelet pool appears to function normally, at least as measured by bleeding time.

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