Asthma and Nonsteroidal Anti-Inflammatory Drugs

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To the editor: We have recently studied (1) a 55-year-old patient suffering from bronchial asthma whose attacks were relieved by aspirin and whose case was in many respects similar to the interesting case recently reported by Kordansky and colleagues (2). In our patient the airway obstruction was strikingly relieved by aspirin and by three other cyclo-oxygenase inhibitors (indomethacin, mefenamate, and fenoprofen), but not by two other analgesics (salicylamide and benzydamine), which do not inhibit prostaglandin biosynthesis. We assumed, therefore, that pharmacologic removal of a product of arachidonic acid cyclo-oxygenation from the respiratory tract of our patient helped him to overcome

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