Antifungal Agents

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To the editor: We read with interest the report by Edwards and colleagues (Ann Intern Med 89:91–106, 1978) on severe candidal infections and new concepts in therapy. We agree with the authors that the suitable antifungal agents for disseminated candidiasis are very few. Moreover, the usefulness of the most reliable agent, amphotericin B sodium deoxycholate complex, is severely limited because of its well-known toxicity. The future of new antifungal drugs does not seem particularly promising, with the probable exception of the amphotericin B water-soluble derivative methyl ester hydrochloride, still under investigation (1). Thus it may be of some interest to

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