Mast Cell Counts

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To the editor: I have read with interest the paper by Yoo, Lessin, and Jensen (Ann Intern Med 88:753–757, 1978) that reports an attempt to quantitate the degree of bone marrow mast cell proliferation in various hematologic disorders. This was accomplished by a semiquantitative counting technique using a calibrated optical micrometre to examine bone marrow aspiration smears. Although this method appears to be reproducible for bone marrow aspiration smears, I question its validity for quantitation of bone marrow mast cell proliferation. It has been previously reported (1) in a subjective evaluation that bone marrow clot sections are far superior to

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