Podophyllin Therapy

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To the editor: The recommendation by Stoehr, Peterson, and Taylor (1) that podophyllin toxicity be prevented by limiting applications to small areas of intact skin is totally unrealistic; what good could that possibly do to a condyloma acuminatum? Their recommendation that the drug be removed after 1 h is also unrealistic; 4 to 6 h is a minimum time, and condylomas that have a pretty stout epithelial covering may require that it be left on for 12 to 24 h.

What they should have recommended is that a “large” condyloma—one measuring, let us say, in excess of 10 to 20

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