Higher Prevalence of HLA-B12 in Patients with IgA Nephropathy

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With the advent of immunofluorescence and electron microscopy, classification of renal disease has become more complex and sophisticated. One clinicopathologic entity that has become well defined is IgA nephropathy (Berger's disease). Patients with this disorder usually manifest normal renal function, hematuria, and minimal proteinuria with a usually benign clinical course (1, 2), although at times the course may be progressive. The symptomatology is often exacerbated by upper respiratory infections. The pathologic hallmarks of the disease are mesangial deposits of IgA with or without other immunoglobulins and complement, and electron dense deposits in the mesangial and subendothelial areas (1, 2).


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