Drugs and Pregnancy

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To the editor: In their article “Safety of Therapy for Allergic Symptoms During Pregnancy” in the August issue, Greenberger and Patterson (1) cited, with permission, data in their Tables 2 and 3 that were originally published by us (our Tables 23.1 and 25.1) (2). The numbers, as presented, are accurate, but the authors do not point out the limited interpretability of our findings, a matter that we emphasized repeatedly throughout our book.

We conducted, quite literally, thousands of comparisons between drug exposures in early pregnancy and various categories of malformations. According to statistical principles, one would expect to find, by

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