Lymphoma and Rifampin

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To the editor: The immunosuppressive effects of rifampin have been well established (1–3). Long-term complications, however, have not yet been reported. We wish to report the case of a patient who developed nasopharyngeal lymphoma after treatment with rifampin for Pott's disease.

A 41-year-old Navajo man presented in June 1974 with a large right paraspinal mass and T6,T7,T8 destruction. He had been taking isoniazid for 2 months because of a positive PPD test (5 TU). His initial treatment was with isoniazid, ethambutol, and streptomycin but was subsequently changed to isoniazid, ethambutol, and rifampin because of the possibility of isoniazid-resistant organisms. He

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