Treatment of Staphylococcal Infection

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To the editor: Wheat, Kohler, and White (1) have provided us with some important data regarding solid-phase radioimmunoassay (RIA) for Staphylococcus aureus antibody and its application to the problem of serious staphylococcal infection. Specifically, they have suggested that the RIA technique may be helpful in differentiating patients with “complicated” from those with “uncomplicated” bacteremia. Included in the group with “complicated” bacteremia, however, are a number of patients whose treatment remains controversial—namely those with a primary focus that is not removed or drained, but without evidence of endocarditis or metastatic abscess. Because the antibody levels in this group of patients, measured

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