Lymph Node Biopsy in Thrombotic Thrombocytopenic Purpura

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Abstract

To the editor: In the article by Goodman and colleagues (1) on the use of gingival biopsy in the diagnosis of thrombotic thrombocytopenic purpura, the authors mention the use of lymph node biopsy in passing but make no further reference.

The article by Amorosi and Ultmann (2) references five reports in which lymph node biopsy was used in making the diagnosis of thrombotic thrombocytopenic purpura during life. Four of the five cases had positive lymph node biopsies. Although this is a small sampling, it does represent a positive biopsy rate of 80%.

In addition to a positive lymph node biopsy

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