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In the past several years, scanning electron microscopy has become one of the popular methods in biology research. Two main technical advancements—improvement of specimen preparation and the improvement of the instrument—are responsible for the massive amount of data that has been generated in a relatively short time and have greatly widened our knowledge concerning a variety of surface features. However, scanning electron microscopic studies of the lymphocyte surface have provided the most excitement as well as generated many controversies. This book presents the current knowledge in this field and is a useful reference, especially for the beginners in this field.