Most nephrologists now recognize that excessive use of analgesics can lead to the development of chronic renal failure, although many other physicians continue to be unaware of the problem. That analgesic-associated nephropathy is an international problem was made clear in a recent symposium (1). Whether analgesic abuse is a major cause of renal disease in the United States is still open to question (2) and needs further study.
The increased incidence of urinary-tract carcinoma among analgesic abusers is sometimes overlooked. In 1965, Hultengren, Lagergren, and Ljungqvist (3) first called attention to this association. They reported a series of 103 patients