Granulomatosis Treatment

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To the editor: In reference to the NIH Conference on vasculitis in the November issue (1), I wish to make a few comments and observations on the treatment of Wegener's granulomatosis and lymphomatoid granulomatosis.

Our experience with Wegener's granulomatosis includes more than 90 cases (2). Cytotoxic agents appear to provide a real advance in treatment. However, the role of glucocorticoids has been inappropriately downgraded. We have maintained patients in a quiescent state solely on prednisone therapy in the range of 60 to 100 mg on alternate days. These patients either could not tolerate or would not use cytotoxic agents for

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