Oxacillin and Hepatotoxicity

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To the editor: The report of Onorata and Axelrod in the October issue (1) emphasizes the otherwise poorly recognized risk of hepatotoxicity from high-dose intravenous oxacillin. However, while I agree that this was probably the agent that induced the observed abnormalities in liver function, the authors' unfortunate statement that none of the other agents their patients were taking “have been associated with hepatic dysfunction” ironically makes them guilty of the same lack of vigilence that made their paper possible.

Of the eight patients cited, six were taking other drugs theoretically capable of inducing injury similar to that seen in these

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