Immunologic Protection Against the Legionnaires' Disease Bacterium in the AKR/J Mouse

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Abstract

Female AKR/J mice were challenged with the Washington strain of Legionnaires' disease (LD) bacteria. Nonimmunized mice inoculated intraperitoneally with 2 X 108 colony forming units became ill within 4 h and died within 24 h. Progressive histopathologic changes initiated as early as 2 h after inoculation involved the lymphoid organs, the crypts of the small intestine, and the liver. Necrosis with minimal inflammatory cell reaction was the primary lesion. Immunization with a soluble LD bacterial antigen failed to prevent illness but protected against death and development of abnormal histologic changes.

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