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Psychopharmacologic agents are widely used in every medical specialty as well as in primary care, with sales in excess of $1 billion annually. Despite the prevalence of functional and emotional disorders in clinical medicine, the average physician is poorly prepared to diagnose or treat these conditions. Few residency programs in internal or family medicine provide adequate training in psychiatry or psychopharmacology. This handbook is an attempt to provide practical guidelines to the nonpsychiatrist for psychotropic drug use based on sound diagnostic and pharmacologic principles. It is an outgrowth of notes originally prepared for junior medical students during their psychiatric clerkship.