Alkaline Phosphatase and Hyperthyroidism

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To the editor: Dr. Cooper and colleagues mention in their recent article “Alkaline Phosphatase Isoenzyme Patterns in Hyperthyroidism” in the February issue (1), that “bone healing in patients with hyperthyroidism may take a prolonged period”; they also observed that “serum alkaline phosphatase may not return to normal for 18 to 24 months after treatment.” Further, they mention that the enzyme pattern of alkaline phosphatase from normal before treatment converts to predominant bone in origin after treatment.Velentzas and colleagues (2) have shown that patients with hyperthyroidism have significantly lower plasma levels of 25 hydroxy-vitamin D than do normal controls subjects.

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