Cimetidine and Impaired Renal Function

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To the editor: Even though there is now extensive experience with the use of Cimetidine, its use in patients with renal failure is still limited. The manufacturer and others have recommended that the dosage of Cimetidine be adjusted when administered to patients with impairment of renal function (1). However, no simple guideline is available, and appropriate attention to the patient's renal status or dosage adjustment, or both, is often not paid. Many reports on possible complications of Cimetidine therapy have involved the administration of normal or increased doses of Cimetidine to patients with renal failure (2). Other reports, including two

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