Massive Amikacin “Overdose”

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Abstract

Amikacin, one of the new aminoglycosides, has been reported to cause nephrotoxicity and ototoxicity (primarily cochlear, but also vestibular) (1–3). To our knowledge, acute massive amikacin overdose has not been previously reported.

On 4 November 1978, a 60-year-old woman with a long history of hypertension was referred to a community hospital for management of acute subarachnoid hemorrhage. At admission, she complained of severe headaches but was alert. Lumbar puncture yielded grossly bloody spinal fluid. She was begun on aminocaproic acid (Amicar®), 3 g intravenously (i.v.) every 2 h. Initial laboratory results were all within normal limits, including a serum creatinine

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