Splenectomy in Sickle-Cell Disease

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To the editor: In the March 1979 Balleston and Warth (1) describe the case of an adult with sickle-cell anemia and splenomegaly who profited from splenectomy. We describe a similar case and relate a different experience.

A 20-year-old woman was seen at the Duke University Medical Center because of recurrent left-upper-quadrant pain and persistent swelling in that area. History showed sickle-cell anemia with hepatosplenomegaly diagnosed at age 3 at the same medical center. Results of physical examination on presentation were remarkable for a protuberant and tender spleen, which extended to the left anterior iliac crest; no hepatomegaly or ascites were

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