Danazol and Thyroid Function

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To the editor: Dr. Spaulding has reported in the May 1979 issue (1) a patient with hereditary angioedema who developed a rise in the level of creatine phosphokinase during treatment with danazol. We have recently reported our experience with this drug in 19 patients with endometriosis (2) but our total experience to date covers 27 patients. When using danazol in doses ranging from 400 to 800 mg daily, clinically significant side-effects were few and affected only three women. One patient developed severe acne, another a transient rash, and a third patient complained of hot flashes and a decrease in the

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