Brucella melitensis Hepatitis: The Absence of Granulomas

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Abstract

Although granulomas are considered to be the characteristic finding in the liver in brucellosis (1), this association has only been well documented in the case of infection due to Brucella abortus (2–7). Almost no information has appeared in the English literature on the histologic changes in the liver during human infection with Brucella melitensis, a species known to produce more fulminant disease than B. abortus (4). We wish to call attention to the different histologic picture that characterizes hepatic involvement in infection due to B. melitensis.

Seven patients seen between 1971 and 1978 with blood-culture-proven brucellosis who underwent percutaneous liver

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