Antibiotic Therapy of Staphylococcal Endocarditis

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To the editor: I read with interest the article in the May issue “Single or Combination Therapy of Staphylococcal Endocarditis in Intravenous Drug Abusers” (1). I am particularly concerned that there was no mention of serumcidal or mean bactericidal concentration. We, too, have been concerned as to whether acute staphylococcal endocarditis could be better treated with single-drug or combination-drug therapy. In our experience, two recent cases in addicts were treated initially with a combination of semisynthetic penicillin and an aminoglycoside. Serumcidal studies pretherapy of 1:8 with demonstration of synergism using a combination of a semisynthetic penicillin and aminoglycoside prompted us

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