Cisplatin and Renal Magnesium Wasting

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To the editor: The efficacy of cisplatin (cis-diamminedichloroplatinum II) in the treatment of solid tumors as well as the side-effects of the agent have been reported. Included in these side-effects are hyperuricemia and hypokalemia (1) Drs. Schilsky and Anderson (2) report an unknown complication of hypomagnesemia and renal magnesium wasting in patients receiving cisplatin in which withdrawal of the cisplatin was associated with normalization of serum magnesemia and absence of renal magnesium wasting. We wish to report an extreme case of hypomagnesemic hypocalcemic tetany with marked hypokalemia secondary to cisplatin in which the drug was continued and electrolyte losses were

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