Hazards of Rapid Administration of Vancomycin

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Recent reviews (1,2) have suggested that 1g of vancomycin be given intravenously immediately before dental procedures, upper respiratory tract surgery, gastrointestinal and genitourinary tract surgery or instrumentation, pelvic examination, dilation and curettage of the uterus, or insertion or removal of an intrauterine device to patients with prosthetic valves or a history of rheumatic fever who cannot receive penicillin. Prophylactic intraoperative administration of vancomycin in neurosurgical patients has also been shown to decrease the incidence of postoperative wound infection, meningitis, cerebritis, and abscess (3).

These reviews indicate that the most serious complications of vancomycin administration are ototoxicity and nephrotoxicity in patients

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