Sulindac and Jaundice

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To the editor: I have recently seen a case of jaundice related to sulindac (Clinoril®; Merck Sharp & Dohme, West Point, Pennsylvania) administration.

A 46-year-old white man was hospitalized because of jaundice. He had been healthy except for neck pain since an injury in 1975. Four months before admission sulindac had been prescribed. He took the drug irregularly and had taken less than 100 tablets (200 mg) in 15 weeks. Because of increased neck pain he began regular use of 200 mg twice daily. Two weeks later he first noted jaundice. He denied any previous episodes of jaundice, gastrointestinal problems,

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