Late Recurrence of Minimal Lesion Nephrotic Syndrome

    loading  Checking for direct PDF access through Ovid


Nephrotic syndrome recurred in 16 patients who had been free of the disease for an interval of 4 to 25 years. Their initial illness began in childhood and responsed to adrenocorticosteroid therapy; in 10 patients it was associated with few changes on light microscopic examination of kidney biopsy specimens. The late recurrence also responded to steroids, and in only 1 patient did low-grade proteinuria persist after treatment. Renal biopsy specimens taken from 8 patients during late recurrence showed minimal-change nephrotic syndrome in 7 and focal segmental glomerulosclerosis in 1. Renal function remained normal in all patients. The late recurrence of minimal-change nephrotic syndrome has most of the features of that syndrome seen in the more typical childhood age group and should be managed similarly.

Related Topics

    loading  Loading Related Articles