Possibly Immunosuppresive Factors in Blood Products

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To the editor: Recent reports of the development of the acquired immunodeficiency syndrome in hemophiliacs receiving factor VIII and other clotting concentrates have prompted immunologic studies of these patients, such as the one reported by deShazo and colleagues (1). The emergence of the syndrome in hemophiliacs has also prompted us to report some of our observations (2) of the immunosuppressive properties of seminal plasma that might help explain their underlying immunosuppression.

The immunosuppressive factor(s) in seminal plasma is possibly linked to transglutaminase activity. Transglutaminases, as they occur in the blood plasma, are more familiarly known as factors XIII and XIIIa

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