To the editor: Allergic reactions to vancomycin are not rare and can be serious when a patient is infected by an organism (usually staphylococci) for which there is no satisfactory alternate antibiotic agent (1, 2). We report the case of a woman infected with a methicillin-resistant Staphylococcus aureus who was twice successfully hyposensitized to vancomycin after she had a severe systemic allergic reaction to the drug.
Our 36-year-old patient had a history of recurrent staphylococcal skin abscesses since childhood. She presented with a chronic, subcutaneous infection of her right elbow and a breast abscess. Both wounds contained methicillin-resistant S. aureus