Thrombocythemia and Neurologic Effects

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To the editor: Jabaily and colleagues have (1) attributed neurologic manifestations in patients with essential thrombocythemia to elevated platelet levels. However, their conclusion is not justified by their data. The commonest neurologic symptom was headache, a nonspecific complaint. One wonders how frequently headache would be reported by age-matched controls who were similarly questioned about neurologic symptoms. Because the authors acknowledge that the needed comparison with a control group was not done, despite the fact that essential thrombocythemia usually occurs in an age group likely to have some signs and symptoms reported in Table 1 of their article, there is no

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