Prostaglandins and Blood Pressure

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To the editor: In his editorial reviewing the role of prostaglandins in the control of blood pressure, Gerber (1) suggests that prostaglandin E2 may act indirectly as a vasodepressor agent by modulation of adrenergic nerve activity because prostaglandin E2 inhibits norepinephrine release from sympathetic nerve endings in response to stimulation in vitro. Gerber further states that “administration of nonsteroidal antiinflammatory agents has not resulted in elevated plasma catecholamine levels during basal or stimulated conditions.”

Administration of drugs such as indomethacin or ibuprofen has in fact decreased rather than increased plasma and urinary catecholamines in normal subjects (2) as well as

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