Diabetes Mellitus Induced by Megestrol Acetate in a Patient with AIDS and Cachexia

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Megestrol acetate has been reported to be a relatively nontoxic drug (1, 2) that is efficacious in the treatment of cachexia associated with the acquired immune deficiency syndrome (AIDS) (3). We report the case of a patient with AIDS who developed diabetes mellitus requiring insulin therapy 13 weeks after beginning megestrol therapy and who experienced an exacerbation of his diabetes when rechallenged with megestrol.

Case Report

A 46-year-old man had been diagnosed with AIDS 2.5 years earlier when a skin biopsy specimen showed Kaposi sarcoma. His treatment regimen is summarized in Figure 1. Before beginning therapy with megestrol acetate, his

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