To the Editors: Cyclophosphamide is widely used in the treatment of cancer and autoimmune diseases (1-3). Several secondary effects have been described in patients treated with this drug, depending on the dose and mode of administration (1, 2). Although blurred vision has occasionally been associated with cyclophosphamide, the mechanism has not been explained (4). We describe a patient with recurrent transitory myopia induced by the intravenous bolus administration of cyclophosphamide bolus in a patient with systemic lupus erythematosus.
A 15-year-old girl was diagnosed as having systemic lupus erythematosus with diffuse proliferative glomerulonephritis. Treatment was begun with daily steroids and monthly