Calcium Supplementation with and without Hormone Replacement Therapy to Prevent Postmenopausal Bone Loss

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To determine whether augmentation of dietary calcium is effective in the prevention of early postmenopausal bone loss.


Three-arm, placebo-controlled, randomized parallel trial. The study duration was 2.9 +/-1.1 (SD) years.


General community.


118 healthy, white women 3 to 6 years after spontaneous menopause, recruited by community announcement.


Random allocation to daily intake of 1700 mg of calcium (calcium carbonate given in divided doses with meals); placebo; or conjugated equine estrogens (0.625 mg; days 1 to 25), progesterone (10 mg; days 16 to 25), and 1700 mg of elemental calcium daily. Each participant received 400 IU of vitamin D daily.

Main Outcome Measures

Total body calcium measured by delayed gamma neutron activation analysis and whole-body counting; bone mineral density of the spine, femur, and radius measured by photon absorptiometry.


Bone mineral density declined in the placebo group for the lumbar spine (-2.1%/y; 95% CI, -3.3 to -0.9), femoral neck (-2.0%/y; CI,-2.6 to -1.2), trochanter (-1.6%/y; CI, -2.4 to -0.8), Ward triangle (-2.7%/y; CI, -3.7 to -1.7), and total body calcium (-2.0%/y; CI, -2.2 to -1.8). Rates of change were intermediate for calcium augmentation compared with placebo and estrogen-progesterone-calcium but statistically significant compared with placebo for total body calcium (-0.5%/y; CI, -0.9 to -0.1; P = 0.006) and the femoral neck (-0.8%/y; CI, -1.4 to -0.2; P = 0.03).


Although less effective than estrogen-progesterone-calcium, calcium augmentation alone significantly retards bone loss from the femoral neck and improves calcium balance in recently postmenopausal women. Dietary calcium augmentation should be recommended as a strategic option in helping to prevent early postmenopausal bone loss.

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