Influence of age on exophthalmos and thyrotrophin receptor antibodies in 123 untreated patients with Graves' disease and 560 normal control subjects

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Abstract

Objective

The influence of age on exophthalmos and thyrotrophin receptor antibodies (TRAb) was studied in untreated patients with Graves' disease (GD). Exophthalmos measurement is useful for GD diagnosis in elderly Japanese patients.

Subjects and methods

Protrusions of the eyes (exophthalmic values: EV) and TRAb were studied in 123 untreated patients with GD and 560 controls. Patients with GD and controls were divided into seven age groups. The receiver operating characteristic (ROC) analysis was done to evaluate the clinical usefulness of EV for GD diagnosis.

Findings

The differences of EV between patients with GD and controls were significant in those aged 60 years and over (≥ 60 years). ROC analysis showed that the sensitivity and specificity of EV were high in elderly groups (≥ 60 years), but not in the others (< 60 years).

Conclusion

Exophthalmic values have clinical usefulness for GD diagnosis in elderly Japanese. An EV has a diagnostic value for GD in elderly patients (≥ 60 years).

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