Correlation Between Dysplastic Lineage and Type of Cytopenia in Myelodysplastic Syndromes Patients With Refractory Anemia According to the FAB Classification

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Abstract

Objectives:

To analyze the correlation between dysplastic lineage and type of cytopenia in myelodysplastic syndromes.

Methods:

We analyzed the correlation between dysplasia and cell count using the data set of our previous morphologic study.

Results:

There were no correlations between dysgranulopoiesis of 10% or more and absolute neutrophil count (ANC). Similarly, hyposegmented mature neutrophils (Pelger) of 10% or more were not related to ANC. Interestingly, the platelet count of patients with dysmegakaryopoiesis (dys Mgk) was higher than that of patients without dys Mgk (dys Mgk ≥10% vs <10%, P = .08; dys Mgk ≥40% vs <40%, P = .02; micromegakaryocytes ≥10% vs <10%, P = .004).

Conclusions:

Since low cell counts did not correlate with the presence of dysplastic features, we suggest that dysplastic features do not directly relate to apoptosis.

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