Optic neuritis is a condition that results in inflammation of the optic nerve and acute visual loss, which requires prompt diagnosis and management when presented to the emergency physician. Although acute optic neuritis is often a common complication of multiple sclerosis, there have been reported cases of infectious origins. Bartonella henselae, the primary bacterial agent responsible for cat scratch disease, can cause optic neuritis and neuroretinitis. There are only a few reported cases of direct tick-to-human transmission of Bartonella; however, we present the first case that resulted in neuroretinitis. The uniqueness of the case as well as the controversy surrounding treatment of this type of infection is discussed.