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Chest compression (CC) quality is associated with rescuer posture and body weight. We designed a Kinect module-based real-time audiovisual feedback (AVF) device to investigate the relationship between rescuer posture, body weight, and CC quality.A total of 100 healthcare professionals were enrolled as participants in this randomized trial. A Kinect-based sensor system was used to monitor the depth and rate of CC and provide further real-time feedback. All participants were asked to perform continuous CC on a manikin with and without feedback for 2 min individually in either a kneeling or standing position.A kneeling posture can provide higher rate of CC than a standing posture can (111.4 ± 22.6 per minute vs. 99.1 ± 18.9 per minute, p value = 0.005). Real-time AVF feedback can provide a better compression depth, rate, and effective compression ratio (6.16 ± 1.88 cm vs. 5.54 ± 1.89 cm, p value = 0.02; 103.2 ± 21.0/min vs. 96.7 ± 25.8/min, p value = 0.03; 62.6 ± 28.0% vs. 51.0 ± 33.2%, p value = 0.004). Regardless of the effect of real-time feedback, the CC depth correlated to the rescuers' body weight. Rescuers who weighed below 71 kg benefited from the Kinect module-based real-time AVF device in terms of improved CC quality.The Kinect-based AVF device can significantly improve CC quality in manikin training in rescuers with their body weight < 71 kg.