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Results of a survey assessing the extent and scope of collaborative drug therapy management (CDTM) in U.S. hospitals are presented.A survey questionnaire was mailed to a national random sample of hospital pharmacies. Pharmacy directors provided data on CDTM activities; their views on support for CDTM, the financial and strategic impact of CDTM, and the effect of state regulations on CDTM practice were assessed using summative Likert-type scales. Logistic regression was performed to assess associations of respondent demographics and hospital characteristics with CDTM use.The usable response rate was 30.2%. Pharmacists were reported to be engaged in CDTM in 66% of respondents’ hospitals, a significantly (p < 0.0001) greater proportion than reported in a comparable 2003 survey. The most prevalent CDTM activities were ordering laboratory and related tests (58.7% of hospitals), adjusting drug strength (57.9%), and changing the frequency of administration (53.8%). The most commonly reported diseases or treatment areas for CDTM use were anticoagulation (52.4% of hospitals), infectious diseases (44.8%), and parenteral nutrition (32.6%).From 2003 to 2013, the prevalence of CDTM use in surveyed U.S. hospitals increased significantly, from about 50% to 66%. The 3 most common specific CDTM activities in 2003—ordering test results, adjusting drug strength, and changing frequency of administration—were still the most common in 2013 but were allowed at higher percentages of hospitals.