Reactive arthritis consists of the classic clinical triad of arthritis, urethritis and conjunctivitis generally occurring within 6 weeks of an infection, typically of the gastrointestinal or genitourinary systems. Staphylococcus aureus is not usually implicated in this condition. Staphylococcal septicemia, while frequently associated with arthralgia, has rarely been associated with a sterile arthritis, although it infrequently results in septic arthritis. It is important to consider reactive arthritis, rather than solely an infectious cause of joint effusions, and arthropathy in a patient with a preceding or ongoing Staphylococcal infection. We report a case of reactive arthritis, in a human leukocyte B27-positive patient, following a recurrent bacterial prostatitis caused by methicillin-resistant S aureus.