Elevated Serum Midkine in Patients With Acute Pancreatitis☆,☆☆

    loading  Checking for direct PDF access through Ovid

Abstract

Background:

Midkine (MK) is reported to be involved in the pathogenesis of numerous pathologies, but the expression of MK in acute pancreatitis (AP) has not been well studied and documented.

Methods:

In this study, the temporal changes of serum MK were assessed in 97 patients with AP by enzyme-linked immunosorbent assay.

Results:

The concentration of serum MK increased along with the severity of AP. Serum MK level increased more significantly in patients with organ failure than in those without organ failure. A more obvious elevation of serum MK level was also observed in patients with pancreatic necrosis.

Conclusion:

Serum MK might be a useful marker in the clinical diagnosis of AP.

Related Topics

    loading  Loading Related Articles