Elevated Serum Midkine in Patients With Acute Pancreatitis☆,☆☆

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Midkine (MK) is reported to be involved in the pathogenesis of numerous pathologies, but the expression of MK in acute pancreatitis (AP) has not been well studied and documented.


In this study, the temporal changes of serum MK were assessed in 97 patients with AP by enzyme-linked immunosorbent assay.


The concentration of serum MK increased along with the severity of AP. Serum MK level increased more significantly in patients with organ failure than in those without organ failure. A more obvious elevation of serum MK level was also observed in patients with pancreatic necrosis.


Serum MK might be a useful marker in the clinical diagnosis of AP.

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