Depression is one of the most common mental health conditions. Many nurses will care for patients who have depression and may be receiving treatment. Treatment often includes the use of medications that affect mood. This article provides a brief overview of the history, indications for use, adverse effects, and nursing considerations regarding antidepressants. This is the second in a series of articles about medications used in the treatment of mental health disorders. For the first article in this series, see “Antipsychotic Medications,” June 2017.