Actions of Interleukin-4 on Prostaglandin Biosynthesis at the Chorion-Decidual Interface

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Abstract

OBJECTIVE

We determined the effects of interleukin-4 on chorion and decidual prostaglandin production.

STUDY DESIGN

Chorion and decidual cells from term placentas were grown to confluence. Cells were then incubated with interleukin-4 either alone or with other known stimulants of prostaglandin production: interleukin-1beta, epidermal growth factor, ionomycin, or phorbol 12-myristate 13-acetate. Prostaglandin E2 production was determined with a specific radioimmunoassay.

RESULTS

Interleukin-4 alone stimulated prostaglandin E2 production in chorion and decidual cells. Interleukin-4 significantly enhanced the stimulatory actions of phorbol 12-myristate 13-acetate, ionomycin, and epidermal growth factor but not interleukin-1beta on prostaglandin E2 production.

CONCLUSION

Interleukin-4 stimulates prostaglandin E2 production by chorion and decidual cells. These data suggest that interleukin-4 production by immune effector cells in gestational tissues may contribute to the pathophysiologic features of preterm labor. (AM J OBSTET GYNECOL 1993;169:1442-7.)

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