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National behavioral health care efforts have opened opportunities to reignite occupational therapy mental health practice and research. The profession's person-centered and occupation-based practice fits well with the growing needs of people with serious mental illness (SMI) served in community-based settings. The nine articles in this special issue provide a growing body of evidence to support the effectiveness of occupational therapy interventions for adults with SMI to enhance health management skills and promote independence in living a balanced and satisfying life. However, much more high-level research is required to explicitly investigate the contributions of occupational therapy in all areas of occupation for adults with SMI and to broaden the available evidence base to inform occupational therapy practice.Nine studies contribute to the growing body of evidence supporting the effectiveness of occupational therapy interventions for adults with SMI to enhance health management skills and promote independence to live a balanced and satisfying life.